Cart
sales@molnova.com
Home - Products - Proteasome/Ubiquitin - Tyrosinase - Tafetinib

Tafetinib

CAS No. 1032265-57-8

Tafetinib( —— )

Catalog No. M34438 CAS No. 1032265-57-8

Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 380 Get Quote
5MG 592 Get Quote
10MG 843 Get Quote
25MG 1224 Get Quote
50MG 1638 Get Quote
100MG 2187 Get Quote
500MG 4392 Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Tafetinib
  • Note
    Research use only, not for human use.
  • Brief Description
    Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.
  • Description
    Tafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibitsstem cell factor receptor (Kit),vascular endothelial growth factor receptor-2 (VEGFR-2),platelet-derived growth factor receptor-β (PDGFR-β),glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), andFms-like tyrosine kinase-3 (FLT3)withIC50values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation ofPDGFR-βandVEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Tyrosinase
  • Recptor
    Tyrosine Kinases
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1032265-57-8
  • Formula Weight
    424.51
  • Molecular Formula
    C24H29FN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1/C(=C/2\C3=C(C(C(NCCN(CC)CC)=O)=C(C)N3)CCC2)/C=4C(N1)=CC=C(F)C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang D, et al. Preclinical anti-angiogenesis and anti-tumor activity of SIM010603, an oral, multi-targets receptor tyrosine kinases inhibitor. Cancer Chemother Pharmacol. 2012;69(1):173-183.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Potassium iodide

    Potassium iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine.

  • EHT 1610

    EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.

  • ZAP-180013

    ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM).

Sign In Join Free