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Sabeluzole
CAS No. 104383-17-7
Sabeluzole( —— )
Catalog No. M34406 CAS No. 104383-17-7
Sabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 126 | In Stock |
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| 10MG | 205 | In Stock |
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| 25MG | 347 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSabeluzole
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NoteResearch use only, not for human use.
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Brief DescriptionSabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.
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DescriptionSabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease.
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In Vitro——
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In VivoAnimal Model:Adult albino male rats (270-330 g) induced by Chlordiazepoxide Dosage:5 mg/kg, 25 mg/kg Administration:SC; 0.5 ml/kg; twice dose with 72 h interval; 1 h before 20 mg/kg Chlordiazepoxide Result:Showed the positive effects on several learning and memory tasks in rats.Did not influence locomotor and rearing activity of animals during the acquisition session.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMicrotubule Associated
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Research Area——
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Indication——
Chemical Information
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CAS Number104383-17-7
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Formula Weight415.52
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Molecular FormulaC22H26FN3O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESFC1=CC=C(OCC(O)CN2CCC(N(C3=NC=4C=CC=CC4S3)C)CC2)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Uberti D, et al. Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Synapse. 1997 Jun;26(2):95-103. ?
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