PGP-4008

CAS No. 365565-02-2

PGP-4008( —— )

Catalog No. M34378 CAS No. 365565-02-2

PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 37 In Stock
5MG 65 In Stock
10MG 105 In Stock
25MG 199 In Stock
50MG 308 In Stock
100MG 461 In Stock
200MG 624 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    PGP-4008
  • Note
    Research use only, not for human use.
  • Brief Description
    PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.
  • Description
    PGP-4008 is a specific P-glycoprotein (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    P-gp
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    365565-02-2
  • Formula Weight
    393.48
  • Molecular Formula
    C26H23N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (158.84 mM; Ultrasonic (<60°C)
  • SMILES
    O=C(Cc1ccccc1)Nc1c2CCN(Cc3ccccc3)c2nc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Brian D Lee, et al. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11;47(6):1413-22.?
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