PGP-4008( —— )

Catalog No. M34378 CAS No. 365565-02-2

PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.

Purity : >98% (HPLC)

COA

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MSDS

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Biological Information

Product Name

PGP-4008
Note

Research use only, not for human use.
Brief Description

PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.
Description

PGP-4008 is a specific P-glycoprotein (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

P-gp
Research Area

——
Indication

——

Chemical Information

CAS Number

365565-02-2
Formula Weight

393.48
Molecular Formula

C26H23N3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (158.84 mM; Ultrasonic (<60°C)
SMILES

O=C(Cc1ccccc1)Nc1c2CCN(Cc3ccccc3)c2nc2ccccc12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Brian D Lee, et al. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11;47(6):1413-22.?

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