PF-00489791( —— )

Catalog No. M34372 CAS No. 853003-48-2

PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

PF-00489791
Note

Research use only, not for human use.
Brief Description

PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.
Description

PF-00489791 (PF-489791) is a potent inhibitor of phosphodiesterase 5A with IC50 of 1.5 nM. PF-00489791 can enhance the relaxation of blood vessels within the kidney and so reduce blood pressure, improving renal function.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

PDE
Recptor

PDE
Research Area

——
Indication

——

Chemical Information

CAS Number

853003-48-2
Formula Weight

476.55
Molecular Formula

C20H28N8O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

C(NS(C)(=O)=O)(=O)C=1C=2C(=C(NC3=CC(C)=CC=N3)N=C(N(CC)C)N2)N(CCOCC)N1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Frank S Menniti, et al. A non-brain penetrant PDE5A inhibitor improves functional recovery after stroke in rats. Restor Neurol Neurosci. 2012;30(4):283-9.?

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