NTRC 0066-0( —— )

Catalog No. M34353 CAS No. 1817791-73-3

NTRC 0066-0 is an orally available, selective and potent inhibitor of threonine tyrosine kinase (TTK) that inhibits phosphorylation of TTK substrates and induces chromosome missegregation in cell lines and mice for cancer research.

Purity : >98% (HPLC)

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Datasheet

HNMR

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Biological Information

Product Name

NTRC 0066-0
Note

Research use only, not for human use.
Brief Description

NTRC 0066-0 is an orally available, selective and potent inhibitor of threonine tyrosine kinase (TTK) that inhibits phosphorylation of TTK substrates and induces chromosome missegregation in cell lines and mice for cancer research.
Description

NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC50=0.9 nM). NTRC 0066-0 can be used for the research of cancer.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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Chemical Information

CAS Number

1817791-73-3
Formula Weight

565.71
Molecular Formula

C33H39N7O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 20.83 mg/mL (36.82 mM; Ultrasonic (<60°C)
SMILES

O=C(NC=1C(=CC=CC1CC)CC)C=2C=CN3C4=NC(=NC=C4CCC23)NC5=CC=C(C=C5OC)N6CCN(C)CC6
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Uitdehaag JCM, et al. Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J Mol Biol. 2017;429(14):2211-2230.?

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