Cart
sales@molnova.com
INCB3619
CAS No. 791826-72-7
INCB3619( —— )
Catalog No. M34284 CAS No. 791826-72-7
INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 416 | In Stock |
|
| 10MG | 588 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameINCB3619
-
NoteResearch use only, not for human use.
-
Brief DescriptionINCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
-
DescriptionINCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity.
-
In VitroApoptosis Analysis.Cell Line:A549 cell Concentration:1, 10 μM Incubation Time:Result:Induced about 3% apoptosis at a concentration of 1 μM and about 5% at a concentration of 10 μM.Cell Viability Assay.Cell Line:NCI-H1666 cell Concentration:0-10 μM Incubation Time:72 h Result:Inhibited proliferation of NCI-H1666 cells.
-
In VivoAnimal Model:BALB/c nu/nu mouse model of A549 xenograft Dosage:50, 60 mg/kg Administration:subcutaneous injection, daily, 14 d Result:Significant tumor growth inhibition and delay at 60 mg/kg dose, less active effect at 50 mg/kg.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorImmunology/Inflammation related
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number791826-72-7
-
Formula Weight413.47
-
Molecular FormulaC22H27N3O5
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(NO)(=O)[C@H]1CC2(CN(C(OC)=O)[C@@H]1C(=O)N3CCC(=CC3)C4=CC=CC=C4)CC2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Bin-Bing S Zhou, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006 Jul;10(1):39-50.?
molnova catalog
related products
-
Neoechinulin A
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways.
-
HA Peptide
Influenza Hemagglutinin (HA) Peptide is a tag peptide derived from an epitope of the influenza hemagglutinin protein.HA Peptide is a highly immunoreactive tag generally used for the separation of tagged proteins from cell culture supernatants and cell lysate under neutral pH conditions and thus are handy tools for coimmunoprecipitation but are also easily detected via western blot.
-
cis VH 032, amine di...
cis VH 032, amine dihydrochloride ((S,S,S)-AHPC) is a negative control for the functionalized VHL ligand VH 032, amine .
