Antipain dihydrochloride

Research use only, not for human use.

Antipain dihydrochloride (Antipain 2HCl) is a protease inhibitor derived from Actinomycetes that exhibits analgesic activity and inhibits X-ray-induced chromosomal aberrations in human lymphocytes.

Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice.

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The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls.Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice.

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Proteasome/Ubiquitin

Serine Protease

Protease

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37682-72-7

677.62

C27H46Cl2N10O6

>98% (HPLC)

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O=CC(CCCNC(N)=N)NC(C(C(C)C)NC(C(CCCNC(N)=N)NC(NC(CC1=CC=CC=C1)C(O)=O)=O)=O)=O.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years