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Phox-I2
CAS No. 353495-22-4
Phox-I2( —— )
Catalog No. M34115 CAS No. 353495-22-4
Phox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 117 | Get Quote |
|
| 5MG | 188 | Get Quote |
|
| 10MG | 282 | Get Quote |
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| 25MG | 453 | Get Quote |
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| 50MG | 660 | Get Quote |
|
| 100MG | 889 | Get Quote |
|
| 500MG | 1782 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePhox-I2
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NoteResearch use only, not for human use.
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Brief DescriptionPhox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks.
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DescriptionPhox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetNADPH
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RecptorNADPH-oxidase
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Research Area——
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Indication——
Chemical Information
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CAS Number353495-22-4
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Formula Weight337.33
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Molecular FormulaC18H15N3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (741.11 mM; Ultrasonic )
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SMILES[O-][N+](=O)c1cccc(c1)C1Nc2ccc(cc2C2C=CCC12)[N+]([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19(2):228-42.?
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