Linetastine( —— )

Catalog No. M34098 CAS No. 159776-68-8

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Product Name

Linetastine
Note

Research use only, not for human use.
Brief Description

Linetastine (TMK-688) is a 5-lipoxygenase inhibitor (5-LOX) that inhibits leukotriene production and antagonizes the effects of histamine.Linetastine is used in studies of asthma, atherosclerosis, and peptic ulcers.
Description

Linetastine is an orally active and potent 5-Lipoxygenase inhibitor. Linetastine shows antihistamine activity. Linetastine inhibits leukotriene production and antagonizes the effect of histamine. Linetastine inhibits the release of leukotrienes B4 and C4 from calcium ionophore-stimulated human leukocytes.
In Vitro

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In Vivo

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Synonyms

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Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Histamine Receptor | Lipoxygenase | LTR
Research Area

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Indication

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CAS Number

159776-68-8
Formula Weight

584.7
Molecular Formula

C35H40N2O6
Purity

>98% (HPLC)
Solubility

——
SMILES

C(OC1CCN(CCNC(/C=C/C=C/C2=CC(OC)=C(OC(OCC)=O)C=C2)=O)CC1)(C3=CC=CC=C3)C4=CC=CC=C4
Chemical Name

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1. Shizawa T, et al. 5-Lipoxygenase inhibitory and antihistamine activities of linetastine. Arzneimittelforschung. 1996 Nov;46(11):1072-6. ?

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