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Azaribine
CAS No. 2169-64-4
Azaribine( —— )
Catalog No. M34055 CAS No. 2169-64-4
Azaribine (2;,3;,5;-Tri-O-acetyl-6-azauridine) is an orotate monophosphate decarboxylase (OMPD) inhibitor with broad-spectrum antiviral activity, inhibiting viral genome replication and gene transcription.Azaribine has been used in the study of Zika virus (ZIKV) infections, and in the study of psoriasis, arthritis and mycosis fungoides.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 38 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 101 | In Stock |
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| 50MG | 144 | In Stock |
|
| 100MG | 212 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAzaribine
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NoteResearch use only, not for human use.
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Brief DescriptionAzaribine (2;,3;,5;-Tri-O-acetyl-6-azauridine) is an orotate monophosphate decarboxylase (OMPD) inhibitor with broad-spectrum antiviral activity, inhibiting viral genome replication and gene transcription.Azaribine has been used in the study of Zika virus (ZIKV) infections, and in the study of psoriasis, arthritis and mycosis fungoides.
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DescriptionAzaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research.
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In VitroCell Cytotoxicity Assay Cell Line:MDCK cells Concentration:0-2 μM Incubation Time:48 h Result:Had cytotoxicity on MDCK cells (CC50=19.66?μM).
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetAntiviral
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RecptorAntiviral
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Research Area——
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Indication——
Chemical Information
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CAS Number2169-64-4
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Formula Weight371.3
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Molecular FormulaC14H17N3O9
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Purity>98% (HPLC)
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Solubility——
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SMILESO(C(C)=O)[C@H]1[C@@H](O[C@H](COC(C)=O)[C@H]1OC(C)=O)N2C(=O)NC(=O)C=N2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jun-Gyu Park, et al. Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses. J Virol. 2020 Mar 17;94(7):e02149-19.?
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