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AZA197
CAS No. 1249398-09-1
AZA197( —— )
Catalog No. M34053 CAS No. 1249398-09-1
AZA197 (AZA-197) is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 299 | Get Quote |
|
| 5MG | 454 | Get Quote |
|
| 10MG | 621 | Get Quote |
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| 25MG | 911 | Get Quote |
|
| 50MG | 1224 | Get Quote |
|
| 100MG | 1575 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAZA197
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NoteResearch use only, not for human use.
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Brief DescriptionAZA197 (AZA-197) is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
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DescriptionAZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number1249398-09-1
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Formula Weight408.58
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Molecular FormulaC24H36N6
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Purity>98% (HPLC)
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Solubility——
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SMILESC(CNC1=NC(NC(CCCN(CC)CC)C)=NC(C)=C1)C=2C=3C(NC2)=CC=CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zins K, et al. Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. J Transl Med. 2013 Nov 27;11:295.?
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