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SCH-336
CAS No. 447459-51-0
SCH-336( —— )
Catalog No. M34024 CAS No. 447459-51-0
SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
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| 5MG | 42 | In Stock |
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| 10MG | 67 | In Stock |
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| 25MG | 155 | In Stock |
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| 50MG | 220 | In Stock |
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| 100MG | 319 | In Stock |
|
| 200MG | 458 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSCH-336
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NoteResearch use only, not for human use.
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Brief DescriptionSCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1.
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DescriptionSCH 336 is a potent, selective, inverse and orally active CB2 agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice.
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In VitroSCH 336 (Sch.336) (0-10 μM) competes with [3H]CP55,940 for binding to human CB2 on Sf9 cell membranes with Ki of 1.8 nM, and decreases GTPγS binding on human CB2-containing membranes with an EC50 of 2 nM, decreases potency on CB1-containing membranes with EC50 of 200 nM.SCH 336 inhibits BaF3/CB2 migration to 100 nM 2-AG with an IC50 of 34 nM.
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In VivoSCH 336 (0.02, 0.2, 2.0 mg/kg; i.p.) significantly inhibits the migration of leukocytes.Animal Model:Female B6D2/F1 mice (HU210) Dosage:0.02, 0.2, 2.0 mg/kg Administration:I.p.Result:Significantly inhibited the migration of leukocytes into the CCL2-soaked gel foam sponge.
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Synonyms——
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCannabinoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number447459-51-0
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Formula Weight539.64
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Molecular FormulaC23H25NO8S3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (185.31 mM; Ultrasonic )
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SMILESS(=O)(=O)(C1=C(S(=O)(=O)C2=CC=C(OC)C=C2)C=C(OC)C=C1)C3=CC=C([C@@H](NS(C)(=O)=O)C)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lunn CA, et al. A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J Pharmacol Exp Ther. 2006 Feb;316(2):780-8.?
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