DB772

Research use only, not for human use.

DB772 is a broad-spectrum antiviral activity that inhibits Bovine Viral Diarrhea Virus (BVDV), prion activity, Border Disease Virus (BDV), HoBi Virus, Forked Horn Virus and Bungowannah Virus.

DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity.

DB772 hydrate (0-100 μM, 96 hours) can inhibit replication of the viruses BVDV2 and BDV at concentrations greater than 0.2 μM, Bungowannah virus replication at concentrations greater than 0.01 μM, and HoBi virus replication greater than 1.65 μM.DB772 hydrate has antiprion activity with CC50 (50% cytotoxic concentration) value of 3.8 μM, TC-EC50 (50% tissue culture effective concentration) value of 0. 8 μM and inhibits PrPSc accumulation in sheep microglia.Cell Viability Assay Cell Line:PrPSc-positive and -negative cell lines of human telomerase-immortalized (hTERT) ovine microglia Concentration:1 μM Incubation Time:4 days Result:Showed no significant effect on cell viability with 96.4% cell viability.Significantly reduced PrPSc-positive spots by 65.8% and completely inhibited PrPSc accumulation in scrapie-infected primary ovine microglia at 4 μM.

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Others

Other Targets

Virus Protease

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1451058-50-6

401.29

C20H18Cl2N4O

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (24.92 mM; Ultrasonic )

C1(N=C(C2=CC=C(C3=CC=C(C4=NCCN4)C=C3)O2)N5)=C5C=CC=C1.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years