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SB 216641 hydrochloride

CAS No. 193611-67-5

SB 216641 hydrochloride( —— )

Catalog No. M33924 CAS No. 193611-67-5

SB 216641 hydrochloride (SB-216641A) is a selective 5-HT1B/D receptor antagonist with anxiolytic properties that antagonizes the vasoconstrictor response mediated by sumatriptan.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SB 216641 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SB 216641 hydrochloride (SB-216641A) is a selective 5-HT1B/D receptor antagonist with anxiolytic properties that antagonizes the vasoconstrictor response mediated by sumatriptan.
  • Description
    SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A inhibits the function of SKF-99101H.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Guinea pigs.Dosage:0.6, 2.0, 6.0 and 20.0 mg/kg.Administration:Intraperitoneal injection; single dose.Result:Significantly blocked the effects of SKF-99101H.Animal Model:Dogs.Dosage:559 nmol/kg. Administration:Intravenous injection; single dose.Result:Improved the gastric relaxation.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    193611-67-5
  • Formula Weight
    523.02
  • Molecular Formula
    C28H31ClN4O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.O=C(NC1=CC=C(OC)C(OCCN(C)C)=C1)C=2C=CC(=CC2)C=3C=CC(=CC3C)C4=NOC(=N4)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hagan JJ, et al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23;331(2-3):169-74. ?
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