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PHA 543613
CAS No. 478149-53-0
PHA 543613( —— )
Catalog No. M33906 CAS No. 478149-53-0
PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 102 | In Stock |
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| 5MG | 104 | In Stock |
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| 10MG | 169 | In Stock |
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| 25MG | 377 | In Stock |
|
| 50MG | 631 | In Stock |
|
| 100MG | 925 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2009 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePHA 543613
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NoteResearch use only, not for human use.
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Brief DescriptionPHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.
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DescriptionPHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research.
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In Vitro——
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In VivoAnimal Model:Male CD-1 mice with (intracerebral hemorrhage) ICH-induction or sham surgeryDosage:4 and 12 mg/kg Administration:Intraperitoneal injection; 4 and 12 mg/kg; 1 hour after surgery Result:Increased p-Akt and decreased p-GSK-3 and CC3 expressions in the ipsilateral hemisphere and reduced the neuronal cell death in the perihematomal area. Attenuated behavioral deficits and brain edema at 72 hours after ICH.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetAChR
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RecptorAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number478149-53-0
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Formula Weight271.31
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Molecular FormulaC15H17N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (921.46 mM; Ultrasonic )H2O : 100 mg/mL (368.58 mM; Ultrasonic)
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SMILESO=C(N[C@H]1CN2CCC1CC2)c1cc2ccoc2cn1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Donn G Wishka, et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. J Med Chem. 2006 Jul 13;49(14):4425-36. ?
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