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PE 154
CAS No. 1192750-33-6
PE 154( —— )
Catalog No. M33905 CAS No. 1192750-33-6
PE 154 is a potent fluorescent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 280 pM and 16 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 155 | In Stock |
|
| 10MG | 250 | In Stock |
|
| 25MG | 432 | In Stock |
|
| 50MG | 635 | In Stock |
|
| 100MG | 882 | In Stock |
|
| 200MG | 1190 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePE 154
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NoteResearch use only, not for human use.
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Brief DescriptionPE 154 is a potent fluorescent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 280 pM and 16 nM respectively.
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DescriptionPE154 (Compound 13) is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50s=280 pM and 16 nM, respectively). PE154 can label β-amyloid plaques in histochemical analysis.
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In Vitro——
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In VivoPE154 (hippocampus injection; 0.2 μg per mouse; once) can stain the histochemical of cortical βamyloid plaques.Animal Model:13–20-month-old triple-transgenic mice harbouring three mutant genes (APPswe, PS-1 and tauP301L)Dosage:0.2 μg per mouse Administration:Hippocampus injection; 0.2 μg per mouse; once Result:Showed the histochemical staining of cortical βamyloid plaques in triple-transgenic (TTG) mice.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetAChE
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RecptorAChE
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Research Area——
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Indication——
Chemical Information
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CAS Number1192750-33-6
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Formula Weight589.68
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Molecular FormulaC35H35N5O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 8.33 mg/mL (14.13 mM; Ultrasonic (<60°C)
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SMILESN(NC(CC1=CC=C(NC=C2C(=O)C=3C(OC2=O)=CC(N(CC)CC)=CC3)C=C1)=O)C4=C5C(=NC=6C4=CC=CC6)CCCC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Paul W Elsinghorst, et al. A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques. Org Biomol Chem. 2009 Oct 7;7(19):3940-6.?
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