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Imeglimin
CAS No. 775351-65-0
Imeglimin( —— )
Catalog No. M33871 CAS No. 775351-65-0
Imeglimin (EMD 387008) is an orally available antidiabetic compound that enhances mitochondrial function, enhances insulin secretion, promotes β-cell proliferation and improves pancreatic β-cell survival in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 75 | In Stock |
|
| 10MG | 121 | In Stock |
|
| 25MG | 225 | In Stock |
|
| 50MG | 356 | In Stock |
|
| 100MG | 524 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1097 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameImeglimin
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NoteResearch use only, not for human use.
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Brief DescriptionImeglimin (EMD 387008) is an orally available antidiabetic compound that enhances mitochondrial function, enhances insulin secretion, promotes β-cell proliferation and improves pancreatic β-cell survival in mice.
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DescriptionImeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function.
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In VitroPreincubation with Imeglimin (10?mM for 4?h or 100?μM for 24?h) fully prevents tert-butylhydroperoxide (tBH)-induced cell death.:Cell Viability Assay Cell Line:Human endothelial cells (HMEC-1) Concentration:100?μM and 10?mM Incubation Time:100?μM for 24?h, 10?mM for 4?hResult:Prevention of cell death.
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In VivoImeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, restores normal glucose tolerance, and improves insulin sensitivity.Animal Model:Male C57BL/6JOlaHsd mice (4 weeks old) Dosage:200 mg/kg Administration:Oral gavage; b.i.d.; 6 weeks Result:A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMitochondrial Metabolism | ROS
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Research Area——
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Indication——
Chemical Information
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CAS Number775351-65-0
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Formula Weight155.2
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Molecular FormulaC6H13N5
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.C[C@@H]1N=C(N)NC(=N1)N(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64(6):2254-64.?
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