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ICI 162,846
CAS No. 84545-30-2
ICI 162,846( —— )
Catalog No. M33867 CAS No. 84545-30-2
ICI 162,846 is an orally active and potent H2 receptor antagonist that inhibits gastric secretion and may be used in the study of duodenal ulcers.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 60 | In Stock |
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| 10MG | 86 | In Stock |
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| 25MG | 141 | In Stock |
|
| 50MG | 204 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameICI 162,846
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NoteResearch use only, not for human use.
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Brief DescriptionICI 162,846 is an orally active and potent H2 receptor antagonist that inhibits gastric secretion and may be used in the study of duodenal ulcers.
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DescriptionICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU.
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In Vitro——
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In VivoAnimal Model:CFLP mice were irradiated to the lower mediastinum to induce CDU.Dosage:10 mg/kg, twice daily for 5 days Administration:Oral gavage (p.o.)Result:Reduced the incidence of CDU. Inhibited gastric acid secretion about 50% or more in the basal and the stimulated periods.Induced massive rises in basal (12-fold) and stimulated (9-fold) luminal histamine.
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorHistamine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number84545-30-2
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Formula Weight306.29
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Molecular FormulaC11H17F3N6O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N)CCCCN1N=C(C=C1)NC(=N)NCC(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wilson JA, et al. Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist. Br J Clin Pharmacol. 1986 Jun;21(6):685-9.?
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