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Home - Products - GPCR/G Protein - Histamine Receptor - ICI 162,846

ICI 162,846

CAS No. 84545-30-2

ICI 162,846( —— )

Catalog No. M33867 CAS No. 84545-30-2

ICI 162,846 is an orally active and potent H2 receptor antagonist that inhibits gastric secretion and may be used in the study of duodenal ulcers.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ICI 162,846
  • Note
    Research use only, not for human use.
  • Brief Description
    ICI 162,846 is an orally active and potent H2 receptor antagonist that inhibits gastric secretion and may be used in the study of duodenal ulcers.
  • Description
    ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU.
  • In Vitro
    ——
  • In Vivo
    Animal Model:CFLP mice were irradiated to the lower mediastinum to induce CDU.Dosage:10 mg/kg, twice daily for 5 days Administration:Oral gavage (p.o.)Result:Reduced the incidence of CDU. Inhibited gastric acid secretion about 50% or more in the basal and the stimulated periods.Induced massive rises in basal (12-fold) and stimulated (9-fold) luminal histamine.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    84545-30-2
  • Formula Weight
    306.29
  • Molecular Formula
    C11H17F3N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N)CCCCN1N=C(C=C1)NC(=N)NCC(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wilson JA, et al. Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist. Br J Clin Pharmacol. 1986 Jun;21(6):685-9.?
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