5-Carboxamidotryptamine maleate( —— )

Catalog No. M33825 CAS No. 74885-72-6

5-Carboxamidotryptamine maleate (5-CT maleate) is a receptor agonist with antihypertensive and glucose-raising effects.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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5MG	128	Get Quote
10MG	203	Get Quote
25MG	351	Get Quote
50MG	492	Get Quote
100MG	664	Get Quote
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Biological Information

Product Name

5-Carboxamidotryptamine maleate
Note

Research use only, not for human use.
Brief Description

5-Carboxamidotryptamine maleate (5-CT maleate) is a receptor agonist with antihypertensive and glucose-raising effects.
Description

5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptors agonist.
In Vitro

[3H]-5-Carboxamidotryptamine (5-CT)binding to 5-HT1D sites in bovine substantia nigra is rapid, reversible and saturable, displaying high affinity (Kd = 0.38 nM) and low non-specific binding. In bovine substantia nigra, [3H]-5-Carboxamidotryptamine (5-CT) labelled an equivalent number of binding sites to [3H]-5-Carboxamidotryptamine (403 and 362 fmol/mg protein, respectively) and binding is sensitive to guanine nucleotides.
In Vivo

Topical 5-Carboxamidotryptamine (0.01-1000 μM) to the exposed dura mater encephala produced decreases in diastolic blood pressure, variable changes in meningeal blood flow and increases in conductance (i.e. dilatation) in the middle meningeal artery of anesthetized Wistar rats (serotonin depletion and treated with 20 mg/kg corticosterone).
Synonyms

——
Pathway

GPCR/G Protein
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

74885-72-6
Formula Weight

319.31
Molecular Formula

C15H17N3O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (156.59 mM; Ultrasonic )H2O : 25 mg/mL (78.29 mM; Ultrasonic)
SMILES

C(=C\C(O)=O)\C(O)=O.C(CN)C=1C=2C(NC1)=CC=C(C(N)=O)C2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. E Martínez-García, et al. 5-HT7 receptor-mediated meningeal dilatation induced by 5-carboxamidotryptamine in rats is not altered by 5-HT depletion and chronic corticosterone treatment. Proc West Pharmacol Soc. 2011;54:57-61.?

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