HKB99( —— )

Catalog No. M33804 CAS No. 2414908-90-8

HKB99 is a mutant inhibitor of phosphoglycerate mutase 1 (PGAM1), which inhibits the growth and metastasis of non-small cell lung cancer.

Purity : >98% (HPLC)

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Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

HKB99
Note

Research use only, not for human use.
Brief Description

HKB99 is a mutant inhibitor of phosphoglycerate mutase 1 (PGAM1), which inhibits the growth and metastasis of non-small cell lung cancer.
Description

HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1). HKB99 inhibits the formation of invasive pseudopodia and increases the level of PAI-2 in vitro. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and ERK. HKB99 can be used for the research of non-small-cell lung cancer (NSCLC).
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Phosphatase
Recptor

Phosphatase
Research Area

——
Indication

——

Chemical Information

CAS Number

2414908-90-8
Formula Weight

450.46
Molecular Formula

C23H18N2O6S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (277.49 mM; Ultrasonic )
SMILES

O=C1C=2C=CC=CC2C(=O)C3=C(O)C(O)=C(C=C13)NS(=O)(=O)C4=CC=C(C=C4)N5CCC5
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Liang Q, et al. HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells. Acta Pharmacol Sin. 2021 Jan;42(1):115-119.?

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