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LY 2389575 hydrochloride
CAS No. 885104-09-6
LY 2389575 hydrochloride( —— )
Catalog No. M33792 CAS No. 885104-09-6
LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 116 | In Stock |
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| 10MG | 187 | In Stock |
|
| 25MG | 407 | In Stock |
|
| 50MG | 594 | In Stock |
|
| 100MG | 828 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1702 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLY 2389575 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionLY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM.
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DescriptionLY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease.
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In VitroReal Time qPCR Cell Line:Microglial cells Concentration:5 μM Incubation Time:1 h Result:Increased levels of Mrc1.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetBeta Amyloid
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RecptorBeta Amyloid | GluR
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Research Area——
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Indication——
Chemical Information
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CAS Number885104-09-6
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Formula Weight438.58
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Molecular FormulaC15H16BrCl3N4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (228.01 mM; Ultrasonic (<60°C); )Methanol : 8.33 mg/mL (18.99 mM; Ultrasonic (<60°C))
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SMILESN(CC1=C(Cl)C=C(Cl)C=C1)[C@@H]2CN(CC2)C=3N=CC(Br)=CN3.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Hoechst 34580
Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.Hoechst 34580 is a good candidate for treating Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner.
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β-Amyloid 13-27
β-Amyloid (13-27) is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein. This synthetic peptide consists of amino acids 26 to 40 of beta amyloid protein. It can be used to study the kinetics of beta amyloid formation.
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PPI-1019
PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).
