Cart
sales@molnova.com
LY 2389575 hydrochloride
CAS No. 885104-09-6
LY 2389575 hydrochloride( —— )
Catalog No. M33792 CAS No. 885104-09-6
LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 78 | Get Quote |
|
| 5MG | 116 | Get Quote |
|
| 10MG | 187 | Get Quote |
|
| 25MG | 394 | Get Quote |
|
| 50MG | 588 | Get Quote |
|
| 100MG | 801 | Get Quote |
|
| 500MG | 1647 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameLY 2389575 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionLY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM.
-
DescriptionLY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease.
-
In VitroReal Time qPCR Cell Line:Microglial cells Concentration:5 μM Incubation Time:1 h Result:Increased levels of Mrc1.
-
In Vivo——
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetBeta Amyloid
-
RecptorBeta Amyloid | GluR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number885104-09-6
-
Formula Weight438.58
-
Molecular FormulaC15H16BrCl3N4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (228.01 mM; Ultrasonic (<60°C); )Methanol : 8.33 mg/mL (18.99 mM; Ultrasonic (<60°C))
-
SMILESN(CC1=C(Cl)C=C(Cl)C=C1)[C@@H]2CN(CC2)C=3N=CC(Br)=CN3.Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Caraci F, et al. Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective. Mol Pharmacol. 2011 Mar;79(3):618-26.?
molnova catalog
related products
-
Buntanetap
Buntanetap ((+)-Phenserine) is an orally active inhibitor of polyneurotoxic proteins (TINAPs) for the study of neurological disorders, endocrine and metabolic disorders, and cardiovascular diseases.
-
AC 253
Amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of Aβ in vitro. Cyclic AC 253 also available.
-
β-Amyloid 12-20
β-Amyloid (12-20) is a peptide fragment of β-Amyloid.Thsis peptide contain the amino acid residues VFF at position (18-20), suggesting that this triad has amnestic effects.
