Cart
sales@molnova.com
IWP-3
CAS No. 687561-60-0
IWP-3( —— )
Catalog No. M33751 CAS No. 687561-60-0
IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 90 | In Stock |
|
| 5MG | 85 | In Stock |
|
| 10MG | 148 | In Stock |
|
| 25MG | 312 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | 807 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameIWP-3
-
NoteResearch use only, not for human use.
-
Brief DescriptionIWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α .
-
DescriptionIWP-3 is an potent inhibitor of Wnt production with an IC50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayWnt/Notch/Hedgehog
-
TargetWnt/beta/catenin
-
RecptorWnt/beta-catenin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number687561-60-0
-
Formula Weight484.59
-
Molecular FormulaC22H17FN4O2S3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (51.59 mM; Ultrasonic (<60°C)
-
SMILESCc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccc(F)cc3)sc2c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Baozhi Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7. ?
molnova catalog
related products
-
TNIK-IN-5
TNIK-IN-5 is an inhibitor of TNIK and can be used in studies about the treatment of anti-tumor and anti-inflammatory diseases.
-
PRI-724 B
PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.
-
IWP-2
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses.
