Cart
sales@molnova.com
Home -
Products -
Antibody Drug Conjugates (ADC) -
ADCs Linker/Click Chemistry -
Gly-Gly-Gly-PEG4-DBCO
Gly-Gly-Gly-PEG4-DBCO
CAS No. 2353409-80-8
Gly-Gly-Gly-PEG4-DBCO( —— )
Catalog No. M33551 CAS No. 2353409-80-8
Gly-Gly-Gly-PEG4-DBCO is a degradable ADC linker containing 4 units of PEG, which can be used to synthesize antibody-conjugated active molecules (ADCs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 188 | In Stock |
|
| 10MG | 271 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameGly-Gly-Gly-PEG4-DBCO
-
NoteResearch use only, not for human use.
-
Brief DescriptionGly-Gly-Gly-PEG4-DBCO is a degradable ADC linker containing 4 units of PEG, which can be used to synthesize antibody-conjugated active molecules (ADCs).
-
DescriptionGly-Gly-Gly-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Gly-Gly-Gly-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
-
In VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
-
In Vivo——
-
Synonyms——
-
PathwayAntibody Drug Conjugates (ADC)
-
TargetADCs Linker/Click Chemistry
-
RecptorADC Linker
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2353409-80-8
-
Formula Weight694.77
-
Molecular FormulaC35H46N6O9
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (143.93 mM; Ultrasonic )Methanol : 50 mg/mL (71.97 mM; Ultrasonic)
-
SMILESO=C(NCC(=O)NCC(=O)NCCOCCOCCOCCOCCNC(=O)CCC(=O)N1C=2C=CC=CC2C#CC=3C=CC=CC3C1)CN
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.?
molnova catalog
related products
-
DBCO-Amine
A simple DBCO-containing building block used to derivatize carboxyl groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond.
-
6-Maleimidohexanoic ...
A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity; a useful protective group in antibody drug conjugates.
-
DOTA-ADIBO
DOTA-ADIBO is a Click Chemistry intermidate used for antibody-drug conjugates.
