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DSPE-PEG4-DBCO
CAS No. 2112738-14-2
DSPE-PEG4-DBCO( —— )
Catalog No. M33549 CAS No. 2112738-14-2
DSPE-PEG4-DBCO is a PEG-based linker for PROTACs that joins two essential ligands, essential for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 73 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 235 | In Stock |
|
| 50MG | 368 | In Stock |
|
| 100MG | 550 | In Stock |
|
| 200MG | 797 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDSPE-PEG4-DBCO
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NoteResearch use only, not for human use.
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Brief DescriptionDSPE-PEG4-DBCO is a PEG-based linker for PROTACs that joins two essential ligands, essential for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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DescriptionDSPE-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DSPE-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPROTACs
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Research Area——
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Indication——
Chemical Information
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CAS Number2112738-14-2
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Formula Weight1282.67
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Molecular FormulaC71H116N3O15P
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Purity>98% (HPLC)
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Solubility——
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SMILESC(CCNC(CCOCCOCCOCCOCCC(NCCOP(OC[C@H](OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)(=O)O)=O)=O)(=O)N1C=2C(C#CC=3C(C1)=CC=CC3)=CC=CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?
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