Cart
sales@molnova.com
DSPE-PEG4-DBCO
CAS No. 2112738-14-2
DSPE-PEG4-DBCO( —— )
Catalog No. M33549 CAS No. 2112738-14-2
DSPE-PEG4-DBCO is a PEG-based linker for PROTACs that joins two essential ligands, essential for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 73 | In Stock |
|
| 10MG | 117 | In Stock |
|
| 25MG | 235 | In Stock |
|
| 50MG | 368 | In Stock |
|
| 100MG | 550 | In Stock |
|
| 200MG | 797 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDSPE-PEG4-DBCO
-
NoteResearch use only, not for human use.
-
Brief DescriptionDSPE-PEG4-DBCO is a PEG-based linker for PROTACs that joins two essential ligands, essential for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
-
DescriptionDSPE-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DSPE-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
-
In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorPROTACs
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2112738-14-2
-
Formula Weight1282.67
-
Molecular FormulaC71H116N3O15P
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(CCNC(CCOCCOCCOCCOCCC(NCCOP(OC[C@H](OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)(=O)O)=O)=O)(=O)N1C=2C(C#CC=3C(C1)=CC=CC3)=CC=CC2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?
molnova catalog
related products
-
G280-9
The G280-9 peptide, a common melanoma gp100 epitope restricted by MHC-associated HLA-A2. The G280-9 sequence is unique because it could be recognized by cytotoxic T lymphocytes at very low concentrations, however it shows low total immunogenicity that may be attributable to relatively low affinity of this peptide for the HLA-A2.
-
Resorcin monoacetate
Resorcinol monoacetate is an antiseptic and a disinfectant, is a chemical intermediate for the production of many other pharmaceuticals, and can be used to treat acne, seborrheic dermatitis, eczema, psoriasis, and other skin disorders.
-
N-Benzylmethylamine
N-Benzylmethylamine is an Alkaloids.
