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Biotin-PEG4-Picolyl azide
CAS No. 2222687-71-8
Biotin-PEG4-Picolyl azide( —— )
Catalog No. M33543 CAS No. 2222687-71-8
Biotin-PEG4-Picolyl azide is a PROTAC linker belonging to the class of PEGs that can be used to synthesize PROTAC molecules.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 258 | In Stock |
|
| 10MG | 416 | In Stock |
|
| 25MG | 661 | In Stock |
|
| 50MG | 913 | In Stock |
|
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBiotin-PEG4-Picolyl azide
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NoteResearch use only, not for human use.
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Brief DescriptionBiotin-PEG4-Picolyl azide is a PROTAC linker belonging to the class of PEGs that can be used to synthesize PROTAC molecules.
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DescriptionBiotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPROTACs
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Research Area——
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Indication——
Chemical Information
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CAS Number2222687-71-8
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Formula Weight622.74
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Molecular FormulaC27H42N8O7S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (200.73 mM; Ultrasonic )
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SMILESC(CCCC(NCCOCCOCCOCCOCCC(NC=1C=CC(CN=[N+]=[N-])=NC1)=O)=O)[C@H]2[C@@]3([C@](CS2)(NC(=O)N3)[H])[H]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?
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