Biotin-PEG4-Picolyl azide( —— )

Catalog No. M33543 CAS No. 2222687-71-8

Biotin-PEG4-Picolyl azide is a PROTAC linker belonging to the class of PEGs that can be used to synthesize PROTAC molecules.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Biotin-PEG4-Picolyl azide
Note

Research use only, not for human use.
Brief Description

Biotin-PEG4-Picolyl azide is a PROTAC linker belonging to the class of PEGs that can be used to synthesize PROTAC molecules.
Description

Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

PROTACs
Research Area

——
Indication

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Chemical Information

CAS Number

2222687-71-8
Formula Weight

622.74
Molecular Formula

C27H42N8O7S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (200.73 mM; Ultrasonic )
SMILES

C(CCCC(NCCOCCOCCOCCOCCC(NC=1C=CC(CN=[N+]=[N-])=NC1)=O)=O)[C@H]2[C@@]3([C@](CS2)(NC(=O)N3)[H])[H]
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?

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