ZXH-3-26 B( —— )

Catalog No. M33536 CAS No. 2243076-67-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

ZXH-3-26 B
Note

Research use only, not for human use.
Brief Description

ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.
Description

ZXH-3-26 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM. The DC50/5h refers to half-maximal degradation after 5 hours of treatment of ~ 5 nM.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

PROTACs
Research Area

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Indication

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CAS Number

2243076-67-5
Formula Weight

785.27
Molecular Formula

C38H37ClN8O7S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 200 mg/mL (254.69 mM; Ultrasonic )
SMILES

CC=1C2=C(N3C([C@H](CC(OC)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C(NCCCCCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)=O
Chemical Name

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1. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.?

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