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ZED-1227
CAS No. 1542132-88-6
ZED-1227( —— )
Catalog No. M33535 CAS No. 1542132-88-6
ZED-1227 (TAK-227) is an orally active, selective and potent transglutaminase 2 (TG2) inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 439 | Get Quote |
|
| 5MG | 615 | Get Quote |
|
| 10MG | 938 | Get Quote |
|
| 25MG | 1684 | Get Quote |
|
| 50MG | 2870 | Get Quote |
|
| 100MG | 4491 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameZED-1227
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NoteResearch use only, not for human use.
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Brief DescriptionZED-1227 (TAK-227) is an orally active, selective and potent transglutaminase 2 (TG2) inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Disease.
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DescriptionZED-1227 is a specific and orally active transglutaminase 2 (TG2) inhibitor,with an IC50 of 45 nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD).
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In VitroZED-1227 (0.1 μΜ-1 μΜ; 24 hours) has no effect on metabolic activity and proliferation in Huh7 cells and CaCo2 cells,that suggests ZED-1227 has no cytotoxic activity.?ZED-1227 (0.002-0.2 mg/mL; 30 minutes) inhibits TG2 in the small intestinal mucosa in vitro.
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In VivoZED-1227 reduces the activity of intestinal TG2 induced by Polyinosinic:Polycytidylic acid (40 mg/kg) to normal control levels and subdues intestinal inflammation in mice.?ZED-1227 (5 mg/kg; i.g.) is able to inhibit TG2 in the small intestinal mucosa.Animal Model:BALB/c miceDosage:5 mg/kg Administration:Oral gavage Result:Inhibited TG2 in vivo in the small intestinal mucosa.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGlutaminase
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Research Area——
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Indication——
Chemical Information
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CAS Number1542132-88-6
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Formula Weight528.6
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Molecular FormulaC26H36N6O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (236.47 mM; Ultrasonic )
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SMILESCCC(CC)CNC(=O)Cn1cccc(NC(=O)[C@H](CC\C=C\C(=O)OC)NC(=O)c2cncn2C)c1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Manu Encalada, et al. The Oral Transglutaminase 2 (TG2) Inhibitor Zed1227 Blocks TG2 Activity in a Mouse Model of Intestinal Inflammation. Gastroenterology. 154(6):S-490.
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