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UPGL00004
CAS No. 1890169-95-5
UPGL00004( —— )
Catalog No. M33526 CAS No. 1890169-95-5
UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM. Kd of UPGL00004 for GAC was 27 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 47 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 72 | In Stock |
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| 25MG | 149 | In Stock |
|
| 50MG | 254 | In Stock |
|
| 100MG | 367 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUPGL00004
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NoteResearch use only, not for human use.
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Brief DescriptionUPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM. Kd of UPGL00004 for GAC was 27 nM.
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DescriptionUPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines.
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In VitroUPGL00004 inhibits MDA-MB-231, HS578T and TSE cells with IC50s of 70, 129, and 262 nM, respectively.
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In VivoThe combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight)via intraperitoneal injection completely prevent any detectable increase in tumor size in a triple-negative breast cancer patient-derived tumor graft model.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGlutaminase
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Research Area——
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Indication——
Chemical Information
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CAS Number1890169-95-5
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Formula Weight534.66
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Molecular FormulaC25H26N8O2S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (233.79 mM; Ultrasonic )
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SMILESO=C(Cc1ccccc1)Nc1nnc(NC2CCN(CC2)c2nnc(NC(=O)Cc3ccccc3)s2)s1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Huang Q, et al. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. J Biol Chem. 2018 Mar 9;293(10):3535-3545.?
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