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TCO-NHS ester
CAS No. 1191901-33-3
TCO-NHS ester( —— )
Catalog No. M33512 CAS No. 1191901-33-3
TCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 86 | In Stock |
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| 10MG | 125 | In Stock |
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| 25MG | 211 | In Stock |
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| 50MG | 332 | In Stock |
|
| 100MG | 532 | In Stock |
|
| 200MG | 759 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTCO-NHS ester
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NoteResearch use only, not for human use.
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Brief DescriptionTCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.
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DescriptionTCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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Synonyms——
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC Linker
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Research Area——
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Indication——
Chemical Information
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CAS Number1191901-33-3
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Formula Weight267.28
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Molecular FormulaC13H17NO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (374.14 mM; Ultrasonic )
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SMILESO=C(OC1CCCC=CCC1)ON1C(=O)CCC1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?
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