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Ropidoxuridine

CAS No. 93265-81-7

Ropidoxuridine( —— )

Catalog No. M33483 CAS No. 93265-81-7

Ropidoxuridine (IPdR) is a novel, orally available halogenated thymidine analogue that holds promise as a sensitizer for human tumors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ropidoxuridine
  • Note
    Research use only, not for human use.
  • Brief Description
    Ropidoxuridine (IPdR) is a novel, orally available halogenated thymidine analogue that holds promise as a sensitizer for human tumors.
  • Description
    Ropidoxuridine (IPdR) is a novel orally available, halogenated thymidine analog and is a potential radiosensitizer for use in human tumors.
  • In Vitro
    Ropidoxuridine is an orally bioavailable pro-drug of IUdR (5-iodo-2'-deoxyuridine). Ropidoxuridine demonstrates strong synergy effects with Alisertib at clinically relevant concentrations.
  • In Vivo
    In an orthotopic tumor model, Ropidoxuridine (750 mg/kg/day) and Alisertib (30 mg/kg/day) demonstrate strong synergy effects.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    93265-81-7
  • Formula Weight
    338.1
  • Molecular Formula
    C9H11IN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (739.43 mM; Ultrasonic )
  • SMILES
    OC[C@H]1O[C@H](C[C@@H]1O)n1cc(I)cnc1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rampurwala MM, et al. Ropidoxuridine (IPdR) potentiates alisertib (MLN8237) activity in triple-negative breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-13-16.
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