PK 11195

Research use only, not for human use.

PK 11195 (RP 52028) is a TSPO ligand for neuroimaging that exhibits significant protection against CoCl2-induced alterations and can be used to study leishmaniasis.

PK 11195 (RP 52028) is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.

Median IC50 values for PK 11195 are 14.2 μM for L. amazonensis, 8.2 μM for L. major, and 3.5 μM for L. braziliensis. The selective index value for L. amazonensis is 13.7, indicating the safety of PK 11195 for future testing in mammals. Time-and dose-dependent reductions in the percentage of infected macrophages, the number of parasites per infected macrophage, and the number of viable intracellular parasites are observed. Electron microscopy reveals some morphological alterations suggestive of autophagy. Interestingly, MCP-1 and superoxide levels are reduced in L. amazonensis-infected macrophages treated with PK 11195.

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Microbiology/Virology

Parasite

Parasite

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85532-75-8

352.86

C21H21ClN2O

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (70.85 mM; Ultrasonic )

CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl

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(-20℃)

With Ice Pack

≥ 2 years