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OGT 2115

CAS No. 853929-59-6

OGT 2115( —— )

Catalog No. M33446 CAS No. 853929-59-6

OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 μM), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    OGT 2115
  • Note
    Research use only, not for human use.
  • Brief Description
    OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 μM), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc).
  • Description
    OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC50 of 0.4 μM. OGT 2115 has anti-angiogenic properties (IC50 of 1 μM). OGT 2115 also inhibits heparan sulfate degradation activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    853929-59-6
  • Formula Weight
    495.3
  • Molecular Formula
    C24H16BrFN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 11.36 mg/mL (22.94 mM; Ultrasonic )
  • SMILES
    OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)\C=C\c2ccc(Br)cc2)c(F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Courtney SM, et al. Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor. Bioorg Med Chem Lett. 2005 May 2;15(9):2295-9.?
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