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ME1111
CAS No. 1391758-52-3
ME1111( —— )
Catalog No. M33428 CAS No. 1391758-52-3
ME1111, a succinate dehydrogenase inhibitor of Trichophyton species, serves as an antifungal agent effective against dermatophytes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 105 | In Stock |
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| 5MG | 95 | In Stock |
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| 10MG | 143 | In Stock |
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| 25MG | 258 | In Stock |
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| 50MG | 349 | In Stock |
|
| 100MG | 496 | In Stock |
|
| 200MG | 643 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameME1111
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NoteResearch use only, not for human use.
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Brief DescriptionME1111, a succinate dehydrogenase inhibitor of Trichophyton species, serves as an antifungal agent effective against dermatophytes.
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DescriptionME1111 is an antifungal agent that is active against dermatophytes. ME1111 is an inhibitor of the succinate dehydrogenase of Trichophyton species. ME1111 has an excellent ability to penetrate human nails and is used for onychomycosis research.
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In VitroME1111 inhibits T. mentagrophytes TIMM 2789, with MICs of 0.5 μg/mL and 0.25 μg/mL in RPMI 1640 medium and SDB, respectively.ME1111 mainly affects the permeability of the cell membrane.ME1111 strongly inhibits the succinate-2,6-dichlorophenolindophenol reductase reaction in Trichophyton rubrum and T. mentagrophytes (IC50: 0.029 μg/mL, 0.025 μg/mL) but only shows moderate inhibition of the same reaction in human cell lines.Cell Viability Assay Cell Line:T. mentagrophytes TIMM 2789 Concentration:0.125 μg/mL, 0.0625 μg/mL Incubation Time:4 hours, 8 hours, 24 hours Result:Inhibited the hyphal growth in a dose-dependent and time-dependent manner, and induced various morphological alterations.
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetAntifungal
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RecptorAntifungal
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Research Area——
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Indication——
Chemical Information
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CAS Number1391758-52-3
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Formula Weight202.25
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Molecular FormulaC12H14N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (494.44 mM; Ultrasonic )
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SMILESCc1cc(C)n(n1)-c1ccc(C)cc1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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