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MB05032
CAS No. 261365-11-1
MB05032( —— )
Catalog No. M33427 CAS No. 261365-11-1
MB05032 is a potent fructose-,-bisphosphatase inhibitor that inhibits gluconeogenesis and reduces d-lactate-triggered ETosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 564 | Get Quote |
|
| 50MG | 733 | Get Quote |
|
| 100MG | 1251 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMB05032
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NoteResearch use only, not for human use.
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Brief DescriptionMB05032 is a potent fructose-,-bisphosphatase inhibitor that inhibits gluconeogenesis and reduces d-lactate-triggered ETosis.
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DescriptionMB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.
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In Vitro——
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In VivoAnimal Model:ZDF rats (8- to 9-week-old (mild diabetes) and 12- to 13-week-old (overt diabetes))Dosage:3, 6, 10, 30, 300 mg/kg (young ZDF rats); 6, 10, 30, 300 mg/kg (aged ZDF rats) Administration:Oral administration; once Result:Results in dose-dependent glucose lowering.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptorPhosphatase
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Research Area——
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Indication——
Chemical Information
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CAS Number261365-11-1
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Formula Weight302.29
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Molecular FormulaC11H15N2O4PS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (165.40 mM; Ultrasonic )
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SMILESO=P(O)(O)C=1OC(=CC1)C=2N=C(SC2CC(C)C)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Erion MD, et al. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5.?
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