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m-PEG12-amine
CAS No. 1977493-48-3
m-PEG12-amine( —— )
Catalog No. M33419 CAS No. 1977493-48-3
m-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12-unit PEG ADC linker used in the synthesis of PROTACs and antibody-drug conjugates (ADCs) .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 46 | In Stock |
|
| 50MG | 72 | In Stock |
|
| 100MG | 110 | In Stock |
|
| 200MG | 161 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Namem-PEG12-amine
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NoteResearch use only, not for human use.
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Brief Descriptionm-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12-unit PEG ADC linker used in the synthesis of PROTACs and antibody-drug conjugates (ADCs) .
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Descriptionm-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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In Vivo——
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Synonyms——
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PathwayAntibody Drug Conjugates (ADC)
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TargetADCs Linker/Click Chemistry
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RecptorADC Linker
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Research Area——
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Indication——
Chemical Information
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CAS Number1977493-48-3
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Formula Weight559.69
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Molecular FormulaC25H53NO12
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (178.67 mM; Ultrasonic )
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SMILESC(OCCOCCOCCOCCOCCOCCN)COCCOCCOCCOCCOCCOC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259.?
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