Bromoenol lactone

Research use only, not for human use.

Bromoenol lactone ((6E)-Bromoenol lactone) is a selective calcium-dependent phospholipase A2 (iPLA2β) and serine protease inhibitor that attenuates nicotine-induced breast cancer cell proliferation and migrations.

Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx.

In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca2+ entry is critical for exocytosis. Bromoenol lactone inhibits exocytosis when stimulated using a Ca2+ ionophore A23187, which passively transports Ca2+ down a concentration gradient and also in permeabilised mast cells where Ca2+ entry is no longer relevant. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca2+ signalling, both the release from internal stores and sustained elevation due to Ca2+ influx.

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Metabolic Enzyme/Protease

Phospholipase

Phospholipase

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88070-98-8

317.18

C16H13BrO2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (157.64 mM; Ultrasonic )

O=C1C(C=2C3=C(C=CC2)C=CC=C3)CC/C(=C\Br)/O1

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(-20℃)

With Ice Pack

≥ 2 years