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Buloxibutid
CAS No. 477775-14-7
Buloxibutid( —— )
Catalog No. M33272 CAS No. 477775-14-7
Buloxibutid (AT2 receptor agonist C21) is a novel and selective small molecule angiotensin II AT2 receptor agonist, exhibiting Ki values of 0.4 nM and 10 μM for AT2 and AT1 receptors, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 148 | In Stock |
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| 25MG | 275 | In Stock |
|
| 50MG | 423 | In Stock |
|
| 100MG | 732 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1469 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBuloxibutid
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NoteResearch use only, not for human use.
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Brief DescriptionBuloxibutid (AT2 receptor agonist C21) is a novel and selective small molecule angiotensin II AT2 receptor agonist, exhibiting Ki values of 0.4 nM and 10 μM for AT2 and AT1 receptors, respectively.
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DescriptionBuloxibutid (AT2 receptor agonist C21) is a agentlike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 μM for the AT2 receptor and AT1 receptor, respectively.
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In Vitro——
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In VivoBuloxibutid, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat, induces outgrowth of neurite cells, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats, and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetRAAS
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RecptorRAAS
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Research Area——
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Indication——
Chemical Information
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CAS Number477775-14-7
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Formula Weight475.62
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Molecular FormulaC23H29N3O4S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (210.25 mM; Ultrasonic )
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SMILESCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004 Nov 18;47(24):5995-6008.?
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