Stilbamidine

Research use only, not for human use.

Stilbamidine (Ba 2652) has antifungal and anticancer activity and can be used to study multiple myeloma and bladder migratory cell carcinoma.

Stilbamidine is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.

The high-affinity pentamidine transporter (HAPT1) is inhibited by Propamidine but displays only low affinity to Stilbamidine. adenosine-sensitive pentamidine transporter (ASPT1), in contrast, is strongly inhibited by Stilbamidine, and Propamidine.[3H]pentamidine uptake is determined in the presence of various concentrations of adenosine (IC50=1.2 μM) or melarsen oxide (IC50=0.7 μM), as well as in the presence of 250 μM adenosine and increasing concentrations of hypoxanthine, Propamidine (IC50=6.1 μM) and Stilbamidine (IC50=110 μM). The two diamidine compounds, Stilbamidine and Pentamidine are used to treat in multiple myeloma, a disease in which increase of the globulin content of the serum is of frequent occurrence.

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Microbiology/Virology

Antifungal

Antifungal

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122-06-5

264.33

C16H16N4

>98% (HPLC)

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N=C(N)C1=CC=C(C=CC2=CC=C(C=C2)C(=N)N)C=C1

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(-20℃)

With Ice Pack

≥ 2 years