SLF( —— )

Catalog No. M33233 CAS No. 195513-96-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

SLF
Note

Research use only, not for human use.
Brief Description

SLF is a synthetic ligand for FKBP12, which increases Ca2+ efflux and protein synthesis to improve skeletal muscle function, and is used in the study of central nervous system diseases and cancer.
Description

SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC.
In Vitro

Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

FKBP | Ligands for Target Protein for PROTAC
Research Area

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Indication

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CAS Number

195513-96-3
Formula Weight

524.65
Molecular Formula

C30H40N2O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (190.60 mM; Ultrasonic (<60°C)
SMILES

C(C(C(CC)(C)C)=O)(=O)N1[C@H](C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC(N)=CC=C3)=O)CCCC1
Chemical Name

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1. Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425.?

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