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OPC-28326
CAS No. 167626-17-7
OPC-28326( —— )
Catalog No. M33227 CAS No. 167626-17-7
OPC-28326 is a specific an α2-adrenergic receptor antagonist and acts as a peripheral vasodilator. OPC-28326 inhibits α2A-, α2B- and α2C-adrenoceptors with Ki of 2040, 285, and 55 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 567 | In Stock |
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| 5MG | 455 | In Stock |
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| 10MG | 620 | In Stock |
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| 25MG | 941 | In Stock |
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| 50MG | 1237 | In Stock |
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| 100MG | 1628 | In Stock |
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| 200MG | 2204 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOPC-28326
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NoteResearch use only, not for human use.
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Brief DescriptionOPC-28326 is a specific an α2-adrenergic receptor antagonist and acts as a peripheral vasodilator. OPC-28326 inhibits α2A-, α2B- and α2C-adrenoceptors with Ki of 2040, 285, and 55 nM, respectively.
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DescriptionOPC-28326 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with Ki of 2040, 285, and 55 nM for α2A-, α2B- and α2C-adrenoceptors, respectively.
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In VitroOPC-28326 enhances endothelial tube formation and promotes microvessel growth. OPC-28326 induces phosphorylation of eNOS and Akt in HAECs in a dose dependent-manner, while it does not affect total amounts of eNOS and Akt. OPC-28326 (1-100?μM) and yohimbine (10-1000?nM) causes a rightward shift in the concentration-response curve of clonidine.
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In VivoOPC-28326 augments blood flow recovery in murine hindlimb ischemia. OPC-28326 significantly increases the number of histologically detectable capillaries in the ischemic leg. OPC-28326 has no beneficial effects on blood flow recovery in eNOS?/? mice. OPC-28326 (3-30?mg/kg, i.v.) and yohimbine causes dose-dependent rightward shift in the pressor dose-response curve induced by B-HT 920. OPC-28326 does not affect on the mydriasis in rats.
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Synonyms——
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PathwayGPCR/G Protein
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TargetAdrenergic Receptor
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RecptorAdrenergic Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number167626-17-7
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Formula Weight421.58
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Molecular FormulaC26H35N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC(=O)(C1=CC(C)=C(NC(CC)=O)C(C)=C1)N2CCC(N(CCC3=CC=CC=C3)C)CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sumi M, et al. OPC-28326, a selective femoral arterial vasodilator, augments ischemia induced angiogenesis. Biomed Pharmacother. 2007 May;61(4):209-15. Epub 2006 Dec 28.?
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