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ZD-0892
CAS No. 171964-73-1
ZD-0892( —— )
Catalog No. M33177 CAS No. 171964-73-1
ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 181 | Get Quote |
|
| 5MG | 278 | Get Quote |
|
| 10MG | 459 | Get Quote |
|
| 25MG | 824 | Get Quote |
|
| 50MG | 1132 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameZD-0892
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NoteResearch use only, not for human use.
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Brief DescriptionZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.
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DescriptionZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.
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In Vitro——
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In VivoZD0892 administration to DBA/2 mice infected with the EMC virus results in reduced myocardial elastolytic activity and coronary microvascular perfusion injury. ZD0892 decreases the pathologic severity of the myocardial lesions associated with murine viral myocarditis. ZD-0892 can reverse advanced pulmonary vascular disease produced in rats.
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetSerine Protease
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RecptorSerine Protease
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Research Area——
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Indication——
Chemical Information
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CAS Number171964-73-1
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Formula Weight499.52
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Molecular FormulaC24H32F3N3O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (500.48 mM; Ultrasonic )
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SMILESCOc1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee JK, et al. A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis. Nat Med. 1998 Dec;4(12):1383-91.?
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