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Home - Products - Proteasome/Ubiquitin - Serine Protease - ZD-0892

ZD-0892

CAS No. 171964-73-1

ZD-0892( —— )

Catalog No. M33177 CAS No. 171964-73-1

ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ZD-0892
  • Note
    Research use only, not for human use.
  • Brief Description
    ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.
  • Description
    ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.
  • In Vitro
    ——
  • In Vivo
    ZD0892 administration to DBA/2 mice infected with the EMC virus results in reduced myocardial elastolytic activity and coronary microvascular perfusion injury. ZD0892 decreases the pathologic severity of the myocardial lesions associated with murine viral myocarditis. ZD-0892 can reverse advanced pulmonary vascular disease produced in rats.
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Serine Protease
  • Recptor
    Serine Protease
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    171964-73-1
  • Formula Weight
    499.52
  • Molecular Formula
    C24H32F3N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (500.48 mM; Ultrasonic )
  • SMILES
    COc1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lee JK, et al. A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis. Nat Med. 1998 Dec;4(12):1383-91.?
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