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TPN171
CAS No. 1229018-87-4
TPN171( —— )
Catalog No. M33154 CAS No. 1229018-87-4
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 352 | In Stock |
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| 5MG | 320 | In Stock |
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| 10MG | 463 | In Stock |
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| 25MG | 701 | In Stock |
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| 50MG | 912 | In Stock |
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| 100MG | 1256 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2520 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTPN171
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NoteResearch use only, not for human use.
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Brief DescriptionTPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH).
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DescriptionTPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research Area——
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Indication——
Chemical Information
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CAS Number1229018-87-4
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Formula Weight441.57
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Molecular FormulaC24H35N5O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (56.62 mM; Ultrasonic (<60°C)
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SMILESCCCOc1ccc(NC(=O)CN2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang Z, et al. Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2019 May 23;62(10):4979-4990.?
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