SR59230A hydrochloride( —— )

Catalog No. M33129 CAS No. 1135278-41-9

SR59230A hydrochloride (SR59230A HCl) is a blood-brain permeable, selective and highly potent β3-adrenergic receptor antagonist that inhibits ultradian brown adipose tissue thermogenesis and interrupts associated paroxysmal brain and body heating.

Purity : >98% (HPLC)

COA

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HPLC

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Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	93	In Stock
5MG	78	In Stock
10MG	112	In Stock
25MG	183	In Stock
50MG	266	In Stock
100MG	393	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

SR59230A hydrochloride
Note

Research use only, not for human use.
Brief Description

SR59230A hydrochloride (SR59230A HCl) is a blood-brain permeable, selective and highly potent β3-adrenergic receptor antagonist that inhibits ultradian brown adipose tissue thermogenesis and interrupts associated paroxysmal brain and body heating.
Description

SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
In Vitro

Cell Viability Assay Cell Line:Three different neuroblastoma (NB) cell lines, one murine (Neuro-2A) and two human (SK-N-BE(2), BE(2)C) Concentration:100 nM, 1 μM, 5 μM, 10 μM, and 50 μM Incubation Time:24 hours Result:Reduced cell viability in a dose-dependent manner, with significant effect at a concentration limit over 1?μM for Neuro-2A cells and 5?μM for SK-N-BE(2) and BE(2)C).
In Vivo

Animal Model:Male C-57BL6J wild-type mice (22-35 g)Dosage:0.5 or 5 mg/kg Administration:Injected s.c.; administered 30 min prior to the injection s.c. of MDMA (20 mg/kg).Result:Modulated the actions of MDMA on temperature involve α1-adrenoceptor antagonism.
Synonyms

——
Pathway

GPCR/G Protein
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

1135278-41-9
Formula Weight

361.91
Molecular Formula

C21H28ClNO2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (690.78 mM; Ultrasonic ) H2O : 2.5 mg/mL (6.91 mM; Ultrasonic)
SMILES

N(C[C@@H](COC1=C(CC)C=CC=C1)O)[C@@H]2C=3C(CCC2)=CC=CC3.Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Nisoli E, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.Mol Pharmacol. 1996 Jan;49(1):7-14.?

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