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SC57666

CAS No. 158959-32-1

SC57666( —— )

Catalog No. M33121 CAS No. 158959-32-1

SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SC57666
  • Note
    Research use only, not for human use.
  • Brief Description
    SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.
  • Description
    SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM.
  • In Vitro
    SC57666 inhibits COX2 with an IC50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC50=6000±1900 nM).
  • In Vivo
    SC57666 has been shown to be orally active (ED50=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    158959-32-1
  • Formula Weight
    316.39
  • Molecular Formula
    C18H17FO2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (316.07 mM )
  • SMILES
    CS(=O)(=O)c1ccc(cc1)C1=C(CCC1)c1ccc(F)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Reitz DB, et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally activeCOX2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878-81.?
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