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SC57666
CAS No. 158959-32-1
SC57666( —— )
Catalog No. M33121 CAS No. 158959-32-1
SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 269 | In Stock |
|
| 5MG | 244 | In Stock |
|
| 10MG | 391 | In Stock |
|
| 25MG | 667 | In Stock |
|
| 50MG | 854 | In Stock |
|
| 100MG | 1107 | In Stock |
|
| 200MG | 1479 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSC57666
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NoteResearch use only, not for human use.
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Brief DescriptionSC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.
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DescriptionSC57666 is a selective COX2 inhibitor with an IC50 of 26 nM.
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In VitroSC57666 inhibits COX2 with an IC50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC50=6000±1900 nM).
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In VivoSC57666 has been shown to be orally active (ED50=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX
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Research Area——
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Indication——
Chemical Information
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CAS Number158959-32-1
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Formula Weight316.39
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Molecular FormulaC18H17FO2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 100 mg/mL (316.07 mM )
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SMILESCS(=O)(=O)c1ccc(cc1)C1=C(CCC1)c1ccc(F)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Reitz DB, et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally activeCOX2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878-81.?
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