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RO5263397

CAS No. 1357266-05-7

RO5263397( —— )

Catalog No. M33107 CAS No. 1357266-05-7

RO5263397 is a TAAR1 specific agonist with oral activity that has been used in antidepressant studies.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 75 In Stock
5MG 68 In Stock
10MG 122 In Stock
25MG 274 In Stock
50MG 400 In Stock
100MG 578 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    RO5263397
  • Note
    Research use only, not for human use.
  • Brief Description
    RO5263397 is a TAAR1 specific agonist with oral activity that has been used in antidepressant studies.
  • Description
    RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult 4-5-month-old male WT littermates (C57BL/6 background) Dosage:0.1, 0.3, 1?mg/kg Administration:p.o.; dosing at the mid-light phase (ZT6)?Result:Increased wake time at 0.3 and 1?mg/kg
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1357266-05-7
  • Formula Weight
    194.21
  • Molecular Formula
    C10H11FN2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 260 mg/mL (1338.76 mM; Ultrasonic )
  • SMILES
    Cc1c(F)cccc1[C@H]1COC(N)=N1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Galley G, et al. Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists.ACS Med Chem Lett.?2015 Dec 30;7(2):192-7.?
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