Pipecuronium bromide

Research use only, not for human use.

Pipecuronium bromide (RGH-1106) is a selective and potent nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker, causing muscle relaxation, often in conjunction with antibiotics.

Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide is a powerful competitive nAChR antagonist with a Kd of 3.06 μM.

Sugammadex has a high affinity for Pipecuronium bromide. As Pipecuronium bromide is about 6 to 7 times more potent than Rocuronium, fewer molecules are required to achieve a comparative blockade than in the case of Rocuronium.

The average ED95 is 0.045mg/kg (0.035-0.059 mg/kg) of Pipecuronium bromide, the onset of action varies between 2 and 6.3 minutes, depending on the dose and the background anesthesia. Pipecuronium bromide does not liberate histamine, it has no cardiovascular side effects even in doses of 3× ED95, and anaphylaxis does not appear to be a problem.Carboxymethylated γ-cyclodextrin shows efficient and complete reversal of the Pipecuronium bromide induced neuromuscular block in an ex vivo rat diaphragm experiment.

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Cell Cycle/DNA Damage

AChR

AChR

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52212-02-9

762.7

C35H62Br2N4O4

>98% (HPLC)

In Vitro:?DMSO : 150 mg/mL (196.67 mM; Ultrasonic ) H2O : 100 mg/mL (131.11 mM; Ultrasonic)

C[C@@]12[C@](C[C@H](N3CC[N+](C)(CC3)C)[C@@H]2OC(C)=O)([H])[C@@]4([H])[C@@](CC1)([H])[C@@]5([C@@](C[C@@H]([C@@H](N6CC[N+](C)(CC6)C)C5)OC(C)=O)([H])CC4)C.[Br-].[Br-]

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(-20℃)

With Ice Pack

≥ 2 years