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Oxythiamine

CAS No. 136-16-3

Oxythiamine( —— )

Catalog No. M33051 CAS No. 136-16-3

Oxythiamine (Hydroxythiamin) is an antivitamin of thiamine and a transketolase (TK) inhibitor.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Oxythiamine
  • Note
    Research use only, not for human use.
  • Brief Description
    Oxythiamine (Hydroxythiamin) is an antivitamin of thiamine and a transketolase (TK) inhibitor.
  • Description
    Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation.
  • In Vitro
    Cell Viability Assay Cell Line:MIA PaCa-2 cells Concentration:0-40 μM Incubation Time:2 days Result:Inhibited cell viability with an IC50 of 14.95 μM.Western Blot Analysis Cell Line:MIA PaCa-2 cells Concentration:0, 5, 50, 500 μM Incubation Time:48 h Result:Inhibited 14-3-3 protein beta/alpha expression, and increased alpha-enolase.
  • In Vivo
    Animal Model:Ehrlich's ascites tumor hosting miceDosage:100-500 mg/kg Administration:i.p., 4 days Result:Inhibited tumor growth by 43% at 300 mg/kg and 84% at 500 mg/kg.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Transketolase | Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    136-16-3
  • Formula Weight
    266.34
  • Molecular Formula
    C12H16N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 51.67 mg/mL (194.00 mM; Ultrasonic )
  • SMILES
    O=C1NC(=NC=C1C[N+]2=CSC(=C2C)CCO)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18. ?
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