OSMI-3( —— )

Catalog No. M33048 CAS No. 2260791-13-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

OSMI-3
Note

Research use only, not for human use.
Brief Description

OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease.
Description

OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells.
In Vitro

OSMI-3 (Compound 2b; 20-50 μM; 4-24 hours; HCT116 cells) treatment significantly reduces O-GlcNAc levels, and has more sustained cellular effects than OSMI-2.A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 in cells treated with OSMI-3 (Compound 2b) is observed. Because OGT knockdown is known to decrease cell proliferation, the effects of OSMI-3 on cell growth in culture over 96h is also monitored. Although there is no evidence of apoptosis, the reduced growth of cells over time is observed, consistent with the knockdown results.Western Blot Analysis Cell Line:HCT116 cells Concentration:20 μM, 40 μM, 50 μM Incubation Time:4 hours, 24 hours Result:Reduced O-GlcNAc levels.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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CAS Number

2260791-13-5
Formula Weight

669.77
Molecular Formula

C32H35N3O9S2
Purity

>98% (HPLC)
Solubility

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SMILES

[C@@H](C(N(CC1=CC=CS1)CC(OCC)=O)=O)(NS(=O)(=O)C=2C=C3C(=CC2)NC(=O)C=C3)C4=C(OCCCC(OCC)=O)C=CC=C4
Chemical Name

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1. Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545.?

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