Oleoylcarnitine

Research use only, not for human use.

Oleoylcarnitine (Oleoyl-L-carnitine) inhibits adenine nucleotide translocase (AdNT) activity with an ic50 of 14 μM.Oleoylcarnitine is an important indicator of neurodegeneration.

Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation.

Oleoylcarnitine (AC18:1) (5, 25, 50 μM; 24, 48 hours) concentration significantly increases in the Dih10 cells with stable CPT2 knock down.Oleoylcarnitine (5 μM, 24 hours) contributes directly to hepatocarcinogenesis by conferring stem cell properties to cancer cells through STAT3 activation.Cell Viability Assay Cell Line:Dih 10 cells, HCC cells Concentration:5, 25, 50 μM Incubation Time:24, 48 hours Result:Enhanced the self-renewal of HCC cells through STAT3 activation.

Oleoylcarnitine (AC18:1) accumulates markedly in obesity-driven HCC tissues of mice.Animal Model:MUP-uPA and PIK3CA Tg mice.Dosage:Administration:High-fat diet (HFD) for miceResult:Accumulated in HCC tissues and in the serum of HFD-fed mice.

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Proteasome/Ubiquitin

Endogenous Metabolite

Endogenous Metabolite

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38677-66-6

425.64

C25H47NO4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (234.94 mM; Ultrasonic (<60°C)

CCCCCCCC\C=C/CCCCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C

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(-20℃)

With Ice Pack

≥ 2 years