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Oleoylcarnitine

CAS No. 38677-66-6

Oleoylcarnitine( —— )

Catalog No. M33043 CAS No. 38677-66-6

Oleoylcarnitine (Oleoyl-L-carnitine) inhibits adenine nucleotide translocase (AdNT) activity with an ic50 of 14 μM.Oleoylcarnitine is an important indicator of neurodegeneration.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Oleoylcarnitine
  • Note
    Research use only, not for human use.
  • Brief Description
    Oleoylcarnitine (Oleoyl-L-carnitine) inhibits adenine nucleotide translocase (AdNT) activity with an ic50 of 14 μM.Oleoylcarnitine is an important indicator of neurodegeneration.
  • Description
    Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation.
  • In Vitro
    Oleoylcarnitine (AC18:1) (5, 25, 50 μM; 24, 48 hours) concentration significantly increases in the Dih10 cells with stable CPT2 knock down.Oleoylcarnitine (5 μM, 24 hours) contributes directly to hepatocarcinogenesis by conferring stem cell properties to cancer cells through STAT3 activation.Cell Viability Assay Cell Line:Dih 10 cells, HCC cells Concentration:5, 25, 50 μM Incubation Time:24, 48 hours Result:Enhanced the self-renewal of HCC cells through STAT3 activation.
  • In Vivo
    Oleoylcarnitine (AC18:1) accumulates markedly in obesity-driven HCC tissues of mice.Animal Model:MUP-uPA and PIK3CA Tg mice.Dosage:Administration:High-fat diet (HFD) for miceResult:Accumulated in HCC tissues and in the serum of HFD-fed mice.
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    38677-66-6
  • Formula Weight
    425.64
  • Molecular Formula
    C25H47NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (234.94 mM; Ultrasonic (<60°C)
  • SMILES
    CCCCCCCC\C=C/CCCCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fujiwara N, et al. CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity. Gut. 2018 Aug;67(8):1493-1504.?
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