ML 145( —— )

Catalog No. M33028 CAS No. 1164500-72-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

ML 145
Note

Research use only, not for human use.
Brief Description

ML 145 is a selective and potent antagonist of human GPR35, with no significant activity against GPR35 in any of its immediate rodent homologs.
Description

ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM). ML 145 has no significant activity for GPR35 at either rodent ortholog.
In Vitro

ML 145 (10 μM) also fully blocks internalization of human FLAG-GPR35-eYFP in response to varying concentrations of Zaprinast, Cromolyn disodium, and Pamoate. ML 145 is either without effect (mouse) or displays only a small and apparently noncompetitive inhibitory effect (rat) at the rodent orthologs. ML 145 acts as a competitive antagonist for a number of agonists at human GPR35 and has an IC50 value against EC80 concentrations of various GPR35 agonists in the region of 20 nM.
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

GPR
Recptor

GPR
Research Area

——
Indication

——

CAS Number

1164500-72-4
Formula Weight

482.57
Molecular Formula

C24H22N2O5S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (103.61 mM; Ultrasonic )
SMILES

C(\C(=C\C1=CC=CC=C1)\C)=C\2/C(=O)N(CCCC(NC3=CC(O)=C(C(O)=O)C=C3)=O)C(=S)S2
Chemical Name

——

1. Heynen-Genel S, et al. Selective GPR35 Antagonists - Probes 1 & 2. National Center for Biotechnology Information (US); 2010-2010 Feb 28.?

Calculator

molnova catalog